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Найден способ уничтожения двойной защиты бактерий от антибиотиков

С момента открытия в 1929 году антибиотиков прошло много лет, и за это время опасные бактерии научились защищаться от своих главных убийц. У них выработались защитные механизмы, и если ученые не найдут действенные способы обойти их, человечество вновь может стать уязвимым к огромному количеству болезней. У некоторых бактерий защита состоит аж из двух слоев — благо, исследователи из Университета Томаса Джефферсона нашли способ уничтожить их за один раз.

Найден способ уничтожения двойной защиты бактерий от антибиотиков

Двумя слоями защиты, например, обладают кишечная палочка и сальмонелла. Если антибиотик и пройдет через один слой клеточной мембраны, второй слой обязательно вытолкнет его обратно. Однако, есть одна лазейка — белки, которые важны для функционирования клеток, вырабатываются транспортной РНК, изменив структуру которой можно провоцировать совершение ошибок.

Чтобы доказать это, исследователи создали инженерные штаммы кишечной палочки и сальмонеллы, лишив их транспортную РНК определенной химической части. Имея «дефектные» молекулы, бактерии не смогли выработать защитные белки, и их клеточные мембраны лишились своей сплоченности. Следовательно, через них смогло пройти больше антибиотических молекул, и бактерии умирали гораздо быстрее.

Мы доказали, что вмешательство в молекулу транспортной РНК наносит вред способности бактериальной клетки вырабатывать мембранные белки, необходимые для защиты от антибиотиков. Скорость уничтожения бактерий крайне важна — чем дольше бактерии умирают, тем больше вероятность развития резистентности.

Я-Минг Хоу, руководитель исследовательской группы

Теперь перед учеными стоит более масштабная задача — им необходимо разработать способ изменения структуры транспортной РНК. Бактерии, использованные в эксперименте, были спроектированы специально, а в природе они они по-прежнему отлично вырабатывают защитные белки.

Примечательно, что некоторые бактерии ради спасения колонии могут даже пожертвовать собой. О том, как это происходит, читайте в нашем материале.

Также не забудьте подписаться на наш Telegram-канал, где всегда публикуются анонсы свежих новостей. Помимо них, там публикуется и другой, не менее интересный контент!

Источник: hi-news.ru

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